2021 Targeted Therapies of Lung Cancer (TTLC) Meeting - Posters-P02. Increase in Tumour PD-L1 Expression in Non-small Cell Lung Cancer Following Thermal Vapour Ablation is Not Related to Systemic Inflammatory Response

P02. Increase in Tumour PD-L1 Expression in Non-small Cell Lung Cancer Following Thermal Vapour Ablation is Not Related to Systemic Inflammatory Response - PDF

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A study presented at the Immunotherapy Biomarkers conference on February 19, 2021, explored the increase in PD-L1 expression in non-small cell lung cancer (NSCLC) after thermal vapor ablation. The researchers aimed to determine whether this increase in PD-L1 expression was related to a systemic inflammatory response. The study included five patients who underwent bronchoscopic thermal vapor ablation prior to surgical lobectomy. Tissue and blood samples were analyzed before and after ablation.<br /><br />The results showed that PD-L1 expression was zero in all patients before ablation. However, after ablation, three out of five patients demonstrated an increase in PD-L1 expression in areas of injured tumor, with positive tumor cells ranging from 20-50% of the tumor area. One patient showed an increase in PD-L1 expression to 5% in areas of viable tumor. The researchers also observed an increase in white cell count, neutrophils, and C-reactive protein levels, indicating an inflammatory response.<br /><br />The study concluded that there was a significant increase in tumor expression of PD-L1 in patients who underwent bronchoscopic thermal vapor ablation. The researchers suggested further investigation of the peripheral blood and tumor microenvironment to understand the degree and quality of the adaptive immune response and its potential for enhancing the clinical response to immune checkpoint inhibitor therapy in NSCLC.<br /><br />This study provides preliminary evidence that thermal ablation may induce changes in PD-L1 expression, potentially enhancing the efficacy of immunotherapy. Further research is needed to explore the relationship between PD-L1 expression, the inflammatory response, and the clinical outcomes of NSCLC patients undergoing ablation therapy.

Asset Subtitle

Kanishka Rangamuwa

Meta Tag

Speaker Kanishka Rangamuwa

Topic Immunotherapy - Biomarkers

Keywords

Immunotherapy Biomarkers conference

PD-L1 expression

non-small cell lung cancer

thermal vapor ablation

systemic inflammatory response

bronchoscopic thermal vapor ablation

tissue and blood samples

white cell count

neutrophils

C-reactive protein levels