2021 Targeted Therapies of Lung Cancer (TTLC) Meeting - Posters-P10. Inhibitory Effect of Pemetrexed Disodium Heptahydrate on the Growth of KRAS-Dependent A549 Lung Cancer Cells

P10. Inhibitory Effect of Pemetrexed Disodium Heptahydrate on the Growth of KRAS-Dependent A549 Lung Cancer Cells

Video Transcription

Video Summary

The video discusses the inhibitory effect of Pimitrex disodium heptidate on the growth of CRAS-dependent A549 lung cancer cells. The figures presented in the video show that Pimitrex induces apoptosis, increases reactive oxygen species (ROS) levels, causes DNA fragmentation, leads to loss of mitochondrial membrane potential, and increases cellular sensors. Additionally, Pimitrex-induced cytotoxicity is explained, indicating that it activates the MPK-M2 pathway and induces autophagy without inhibiting the RAS-REF-MEC-ERK signaling pathway. These findings highlight the potential of Pimitrex as a treatment for lung cancer.

Asset Subtitle

Md Mohiddin

Meta Tag

Speaker Md Mohiddin

Topic Targeted Therapies - KRAS

Keywords

Pimitrex disodium heptidate

CRAS-dependent A549 lung cancer cells

apoptosis

reactive oxygen species (ROS)

mitochondrial membrane potential