2021 World Conference on Lung Cancer (Posters)-FP07. Effect of Tumor Treating Fields (TTFields) on DNA Damage and The FA-BRCA DNA Repair Pathway in Mesothelioma

FP07. Effect of Tumor Treating Fields (TTFields) on DNA Damage and The FA-BRCA DNA Repair Pathway in Mesothelioma

Video Transcription

Video Summary

The video discusses the effect of tumor treating fields (DD fields) on DNA damage and the Fanconia anemia BRCA DNA repair pathway in mesothelioma. DD fields are low intensity, intermediate frequency alternating electron fields used as an anti-cancer treatment. The research found that DD fields caused elevated DNA damage and reduced expression of proteins involved in DNA repair in mesothelioma cells. The combination of DD fields with cisplatin showed a synergistic effect, indicating increased efficacy. These findings provide insights into the mechanism of action of DD fields for the treatment of mesothelioma.

Asset Subtitle

Eyal Dor-On

Meta Tag

Speaker Eyal Dor-On

Topic Mesothelioma, Thymoma and Other Thoracic Malignancies

Keywords

tumor treating fields

DD fields

DNA damage

Fanconia anemia BRCA DNA repair pathway

mesothelioma