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2021 World Conference on Lung Cancer (Posters)
FP09. Phase II Randomized Trial to Evaluate Predni ...
FP09. Phase II Randomized Trial to Evaluate Prednisone Taper With or Without Nintedanib for the Treatment of Radiation Pneumonitis
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Video Summary
This presentation discusses the results of a phase 2 randomized controlled trial on the use of Nintendonib for the treatment of radiation pneumonitis. Radiation pneumonitis is a common toxicity of radiation treatment, leading to symptoms such as cough, fever, and respiratory insufficiency. The study aimed to determine whether Nintendonib, a multiple tyrosine kinase inhibitor, would decrease the incidence of acute exacerbations and long-term pulmonary function decline in patients with radiation pneumonitis. The study involved 30 eligible patients, and while there was a trend towards greater freedom from pulmonary exacerbations with Nintendonib, the difference was not statistically significant. The study was limited by low accrual, and further evaluation of Nintendonib is needed. Secondary endpoints will be reported in the future.
Asset Subtitle
Zachary R Moore
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Speaker
Zachary R Moore
Topic
Novel Therapeutics and Targeted Therapies
Keywords
phase 2
randomized controlled trial
Nintendonib
radiation pneumonitis
tyrosine kinase inhibitor
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