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2021 World Conference on Lung Cancer (Posters)
FP12. Obesity is Associated With Greater Overall S ...
FP12. Obesity is Associated With Greater Overall Survival in Patients With Metastatic NSCLC Receiving First-Line Pembrolizumab
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Video Summary
This presentation discusses a study investigating the association between obesity and overall survival in metastatic non-small-cell lung cancer patients receiving first-line Pembrolizumab therapy. The study found that obese patients had significantly longer overall survival compared to non-obese patients. Possible explanations for this association include a dysfunctional immune state in obese patients, which may make them more responsive to Pembrolizumab, or the physiological advantage of having a larger reserve that slows the progression of cachexia. However, the study acknowledges that further research is needed to determine whether this association is true or due to other factors. Additionally, alternative measures of obesity and body composition should be explored.
Asset Subtitle
Findlay David Thomson
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Speaker
Findlay David Thomson
Topic
Predictive Tumor Based Assays/ Biomarkers/ Pathology
Keywords
obesity
overall survival
metastatic non-small-cell lung cancer
Pembrolizumab therapy
immune state
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