2021 World Conference on Lung Cancer (Posters)-FP14. Small Cell Lung Carcinoma’s Clinical Versatility Is a Manifestation of Its Shape-Shifting Cellular Programs

FP14. Small Cell Lung Carcinoma’s Clinical Versatility Is a Manifestation of Its Shape-Shifting Cellular Programs

Video Transcription

Video Summary

The presenter discusses the heterogeneity and cellular programs of small cell lung carcinoma (SCLC). They reveal that treatment naive SCLCs are more diverse than previously thought, with most tumors containing two or more subpopulations. They identify transcriptional states marked by genes such as acute scoot, neuro D1, and yap one. The frequency of each state varies across tumors, and there is significant interconversion between states within individual tumors. This study provides insight into the cellular dynamics and program diversity of SCLC, leading to the development of therapeutic strategies aimed at limiting its plasticity.

Asset Subtitle

Mohamed E. Abazeed

Meta Tag

Speaker Mohamed E. Abazeed

Topic Yes

Keywords

small cell lung carcinoma

SCLC

treatment naive

cellular programs

transcriptional states