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2021 World Conference on Lung Cancer (Posters)
FP16. A Nationwide Population-Based Mapping of Mut ...
FP16. A Nationwide Population-Based Mapping of Mutations and Gene Fusions in Lung Cancer Among Never-Smokers
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Video Summary
Annette Salomonsson from Lund University presented a project on mapping mutations and gene fusions in lung cancer among never smokers in Sweden. Through the National Lung Cancer Registry, 439 tumor samples were analyzed. The nonostring encounter element assay was used to detect gene fusions and methoxone-14 skipping, while a 15 or 26 gene exome-focused NGS panel was used for mutation analysis. Results showed that 25% of the cases had alterations, with the most common being methoxone-14 skipping, ALK fusions, and RET fusions. Among the 138 samples analyzed with both assays, 85% showed alterations in targetable or potentially targetable genes.
Asset Subtitle
Annette Salomonsson
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Speaker
Annette Salomonsson
Topic
Tumor Biology and Systems Biology: Basic and Translational Science
Keywords
lung cancer
gene fusions
mutation analysis
targetable genes
never smokers
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