2021 World Conference on Lung Cancer (Posters)-FP16. A Nationwide Population-Based Mapping of Mutations and Gene Fusions in Lung Cancer Among Never-Smokers

FP16. A Nationwide Population-Based Mapping of Mutations and Gene Fusions in Lung Cancer Among Never-Smokers

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Video Summary

Annette Salomonsson from Lund University presented a project on mapping mutations and gene fusions in lung cancer among never smokers in Sweden. Through the National Lung Cancer Registry, 439 tumor samples were analyzed. The nonostring encounter element assay was used to detect gene fusions and methoxone-14 skipping, while a 15 or 26 gene exome-focused NGS panel was used for mutation analysis. Results showed that 25% of the cases had alterations, with the most common being methoxone-14 skipping, ALK fusions, and RET fusions. Among the 138 samples analyzed with both assays, 85% showed alterations in targetable or potentially targetable genes.

Asset Subtitle

Annette Salomonsson

Meta Tag

Speaker Annette Salomonsson

Topic Tumor Biology and Systems Biology: Basic and Translational Science

Keywords

lung cancer

gene fusions

mutation analysis

targetable genes

never smokers