2021 World Conference on Lung Cancer (Posters)-P70. Clinicopathological and Genetic Ancestry Impact of TP53 Mutations in Brazilian Lung Adenocarcinoma Patients

P70. Clinicopathological and Genetic Ancestry Impact of TP53 Mutations in Brazilian Lung Adenocarcinoma Patients

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Video Summary

The study presented by Rodrigo focuses on the frequency and impact of GP53 mutations in lung adenocarcinoma patients in Brazil. The researchers analyzed data from 366 lung adenocarcinoma patients and found that 60% of them harbored GP53 mutations. These mutations were associated with younger age at diagnosis, worse performance status, metastases at diagnosis, and tobacco exposure. The study also evaluated the genetic ancestry background of the patients and found that GP53 mutations were associated with higher African ancestry and lower European ancestry. Regarding overall survival, patients with GP53 mutations had shorter overall survival, but GP53 mutations were not an independent factor associated with the risk of death.

Asset Subtitle

Rodrigo de Oliveira Cavagna

Meta Tag

Speaker Rodrigo de Oliveira Cavagna

Topic Tumor Biology and Systems Biology: Basic and Translational Science

Keywords

GP53 mutations

lung adenocarcinoma

Brazil

frequency

impact