2022 World Conference on Lung Cancer (Posters)-P1.01-01. Comparison between Protein and Autoantibody Biomarkers for the Early Detection of Lung Cancer

Pdf Summary

This study compared the effectiveness of protein biomarkers and the autoantibody-based EarlyCDT-Lung test in detecting lung cancer at an early stage. The EarlyCDT-Lung test is a pre-screening test that aims to identify individuals who may benefit from lung cancer screening. The study aimed to evaluate the EarlyCDT-Lung test's ability to predict incident lung cancer in the general population and compare it with a protein-based risk model.<br /><br />The study analyzed data from two European population cohorts, including a development set and a validation set. The characteristics of the study participants, including age, sex, BMI, smoking history, and eligibility for lung cancer screening, were assessed.<br /><br />The results showed that the EarlyCDT-Lung test had a low sensitivity of 14% and a specificity of 86% for incident lung cancer overall. In comparison, the protein-based risk model had a higher sensitivity of 49% at the same specificity level. The protein-based risk model also outperformed the EarlyCDT-Lung test in all evaluated subgroups.<br /><br />Furthermore, the area under the curve (AUC) for the protein-based risk model in the validation sample was 0.75, compared to 0.64 for the PLCOm2012 model. This indicated that the protein-based risk model had better predictive accuracy.<br /><br />In conclusion, the EarlyCDT-Lung test had a low sensitivity in predicting lung cancer when measured in pre-diagnostic blood samples collected up to three years prior to diagnosis. The study found that alternative risk assessment tools, including the protein-based risk model, outperformed the EarlyCDT-Lung test. The study suggests that further evaluation of circulating proteins as biomarkers for lung cancer screening is needed.

Asset Subtitle

Xiaoshuang Feng, France

Meta Tag

Speaker Xiaoshuang Feng, France

Topic Early Detection and Screening – Biomarkers

Keywords

protein biomarkers

autoantibody-based EarlyCDT-Lung test

lung cancer

early stage

pre-screening test

incident lung cancer

protein-based risk model

European population cohorts

sensitivity

specificity