2022 World Conference on Lung Cancer (ePosters)-EP01.01-009. Common MicroRNAs in Pre-diagnostic Serum Associated with Lung Cancer in Two Cohorts up to Eight Years Before Diagnosis: A HUNT Study

EP01.01-009. Common MicroRNAs in Pre-diagnostic Serum Associated with Lung Cancer in Two Cohorts up to Eight Years Before Diagnosis: A HUNT Study

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Researchers from several institutions, including the Norwegian University of Science and Technology, have discovered potential blood biomarkers for the early detection of lung cancer. Using next-generation sequencing on blood samples from a population of non-cancer, ever-smokers up to eight years before diagnosis, the study aimed to identify and validate novel biomarkers. The study used two large prospective population health studies, HUNT2 and HUNT3, and included 240 samples in the discovery set and 72 samples in the validation set. The researchers identified nine unique microRNAs in the serum samples that showed potential as biomarkers for lung cancer. Additionally, three microRNAs were found to be associated with non-small cell metastatic lung cancer. When these three microRNAs were analyzed as a signature, they showed promise as a diagnostic tool for lung cancer, with an area under the curve (AUC) of 0.90 in the validation set. These findings suggest that these microRNAs could be used as early diagnostic or prognostic biomarkers for lung cancer. However, further validation in a larger prospective serum dataset is needed to confirm these results.

Asset Subtitle

Oluf Røe, Norway

Meta Tag

Speaker Oluf Røe, Norway

Topic Early Detection and Screening - Biomarkers

Keywords

blood biomarkers

early detection

lung cancer

next-generation sequencing

non-cancer smokers

biomarker validation

prospective population health studies

serum samples

microRNAs

diagnostic tool