2022 World Conference on Lung Cancer (ePosters)-EP01.04-002. The Impact of Enforcing a Structure in Lung Cancer Screening Strategy on the Effectiveness and Efficiency of the Screening Program

EP01.04-002. The Impact of Enforcing a Structure in Lung Cancer Screening Strategy on the Effectiveness and Efficiency of the Screening Program

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This document presents the results of a study that assessed the impact of imposing a structured lung cancer screening strategy on the effectiveness and efficiency of the screening program. The study compared different screening policies, including the 2021 US Preventive Services Task Force (USPSTF) recommendation, using the ENGAGE framework, which provides personalized screening recommendations based on individual characteristics.<br /><br />The findings of the study showed that the effectiveness of the screening program, in terms of quality-adjusted life-years (QALYs) gained, was not significantly affected by imposing a structure into the screening strategy. However, imposing a structure did affect the efficiency of the screening program.<br /><br />The study compared six different structured screening policies with the 2021 USPSTF recommendation. The results showed that a biennial screening between 50-64 years followed by annual screening between 65-80 years was more efficient in terms of the number of low-dose CT (LDCT) exams needed and the number of false-positive findings compared to the 2021 USPSTF recommendation. However, this policy yielded comparable effectiveness in terms of mortality reduction and QALYs gained.<br /><br />The ENGAGE framework, which takes into account individual factors such as age, sex, smoking intensity, age at smoking initiation, age at smoking cessation, and screening history, was used to provide optimal screening decisions at the individual level.<br /><br />The study concluded that imposing a structure on the screening schedule could improve the efficiency of the screening program without compromising its effectiveness. However, the findings should be generalized with caution as the policies were evaluated on a specific population of ever smokers who started smoking at age 18 and quit at age 45.<br /><br />Overall, the study provides valuable insights into the impact of structured lung cancer screening strategies and highlights the potential benefits of personalized and dynamic screening schedules.

Asset Subtitle

Iakovos Toumazis

Meta Tag

Speaker Iakovos Toumazis

Topic Early Detection and Screening - Implementation Quality Control

Keywords

lung cancer screening

structured screening strategy

screening program effectiveness

screening program efficiency

USPSTF recommendation

ENGAGE framework

personalized screening recommendations

quality-adjusted life-years

biennial screening

low-dose CT exams