2022 World Conference on Lung Cancer (ePosters)-EP01.07-004. FDG-PET-CT for Staging Screen Detected Lung Cancer

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This study examined the utility of FDG-PET-CT for staging screen-detected lung cancers. The researchers conducted a retrospective review of biopsy-proven lung cancers from three lung cancer screening trials in Vancouver, Canada. All participants had a PET-CT as part of the staging protocol.<br /><br />The study found that PET-CT provides useful staging information for screen-detected lung cancers that are 1cm or larger (stage 1A1). However, PET-CT was not as effective for smaller tumors or tumors presented as part-solid or non-solid nodules.<br /><br />The researchers also found that EBUS bronchoscopy plays a role in the pre-operative assessment of lung cancers. There was good agreement between PET-CT and final pathology stage, with a kappa value of 0.83. However, EBUS had even better agreement with final pathology stage, with a kappa value of 0.93.<br /><br />The study also showed that CT-PET over-staged nodal involvement in 8.5% of cases and under-staged it in 7.7% of cases. This suggests that PET-CT may not accurately predict the extent of nodal involvement in lung cancers.<br /><br />Overall, the study suggests that PET-CT can provide useful staging information for larger screen-detected lung cancers, but other imaging modalities such as EBUS should also be considered for more accurate staging. The findings of this study have implications for the peri-operative management and planning of screen-detected lung cancers.

Asset Subtitle

Renelle L Myers

Meta Tag

Speaker Renelle L Myers

Topic Early Detection and Screening - Work Up

Keywords

FDG-PET-CT

screen-detected lung cancers

staging

retrospective review

lung cancer screening trials

EBUS bronchoscopy

final pathology stage

CT-PET

nodal involvement

imaging modalities