2022 World Conference on Lung Cancer (ePosters)-EP02.01-009. PD-L1 Expression in Biopsies and Surgical Specimens of Lung Cancer: Impact of Biopsy Methods and Neoadjuvant Therapy

EP02.01-009. PD-L1 Expression in Biopsies and Surgical Specimens of Lung Cancer: Impact of Biopsy Methods and Neoadjuvant Therapy

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The study examined the correlation of PD-L1 expression on tumor cells between diagnostic biopsies and surgical specimens in lung cancer patients, focusing on the impact of biopsy techniques and neoadjuvant treatment. PD-L1 testing is commonly performed on biopsy specimens, but there are concerns about whether these small tissue samples accurately represent the true PD-L1 expression of the tumor.<br /><br />The researchers conducted a retrospective study comparing PD-L1 expression on tumor cells from different biopsy techniques, including bronchoscopy brush cytology, endobronchial-ultrasound guided transbronchial needle aspiration (EBUS-TBNA), endobronchial biopsy, transbronchial biopsy (TBB), and computed tomography (CT)-guided transthoracic biopsy. They compared these results to the PD-L1 expression of the corresponding surgical resection.<br /><br />The study found a statistically significant correlation between PD-L1 expression on tumor cells in biopsies and resected specimens, but the clinical accuracy of this correlation was uncertain. Using a cut-off value of 50% PD-L1 TPS (tumor proportion score), the concordance rate was 78% with a moderate agreement. Therefore, caution should be exercised in interpreting the PD-L1 status determined from biopsy specimens for treatment decisions.<br /><br />The study included a total of 113 lung cancer patients, with 60% male and a mean age of 65 years. The correlation between PD-L1 expression on tumor cells was significant for patients without neoadjuvant treatment and those who underwent neoadjuvant treatment.<br /><br />The researchers also provided data on neoadjuvant treatment options, histology of the tumors, and the distribution of biopsy techniques used in the study.<br /><br />In conclusion, there was a correlation between PD-L1 expression on tumor cells in biopsies and surgical specimens, but the clinical accuracy of this correlation is uncertain. Therefore, caution is recommended when using PD-L1 expression from biopsy specimens for treatment decisions.

Asset Subtitle

Mir Alireza Hoda

Meta Tag

Speaker Mir Alireza Hoda

Topic Early Stage Non-small Cell Lung Cancer - Biomarkers

Keywords

PD-L1 expression

tumor cells

diagnostic biopsies

surgical specimens

lung cancer patients

biopsy techniques

neoadjuvant treatment

cut-off value

concordance rate

treatment decisions