2022 World Conference on Lung Cancer (ePosters)-EP02.02-003. Mean Lung Dose Correlates with Volume of Radiation-Induced Lung Injury in Patients Treated with SABR for Lung Cancer

EP02.02-003. Mean Lung Dose Correlates with Volume of Radiation-Induced Lung Injury in Patients Treated with SABR for Lung Cancer

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A study was conducted to investigate whether dosimetric data correlates with the volume of radiation-induced lung injury (RILI) in patients receiving stereotactic ablative body radiotherapy (SABR) for lung cancer. The study included 21 patients who underwent SABR treatment and their post-treatment scans were imported into radiotherapy planning software. The relative volume of lung damage (RVLD) was calculated and the mean treated lung dose (MTLD) was obtained from the treatment plans. <br /><br />The findings of the study showed that patients with a higher degree of lung damage at 12 months post-SABR had a higher MTLD on treatment planning. The mean lung dose was found to correlate with the relative volume of radiation-induced lung injury visible on post-treatment CT scans at both the 4 and 12-month time points. <br /><br />These findings suggest that dosimetric data may be useful in predicting the degree of expected lung injury, which can help interpret post-treatment imaging and identify patients at higher risk of radiation-induced lung injury. <br /><br />The median relative volumes of lung damage at 4 and 12 months were found to be 0.49% and 1.13% respectively. The difference in RVLD between the time points was not statistically significant. <br /><br />Further analysis showed that at 12 months post-SABR, patients with higher relative volumes of lung damage had a significantly higher median MTLD compared to those with lower volumes. At 4 months post-SABR, patients with higher relative volumes of lung damage also had a higher median MTLD, although this was not statistically significant. <br /><br />Regression analysis demonstrated a correlation between the mean treated lung dose and the relative volume of lung damage at both the 4 and 12-month time points post-SABR. <br /><br />In conclusion, this study highlights the significance of dosimetric data in predicting and understanding radiation-induced lung injury in patients receiving SABR for lung cancer. These findings have the potential to aid in clinical decision-making and the interpretation of post-treatment imaging.

Asset Subtitle

Angus John Killean

Meta Tag

Speaker Angus John Killean

Topic Early Stage Non-small Cell Lung Cancer - Radiotherapy

Keywords

dosimetric data

volume of radiation-induced lung injury

stereotactic ablative body radiotherapy

lung cancer

post-treatment scans

radiotherapy planning software

relative volume of lung damage

mean treated lung dose

post-treatment CT scans

expected lung injury