2022 World Conference on Lung Cancer (ePosters)-EP02.02-007. Correlation between Biological Equivalent Dose and Radiological Changes after Lung Stereotactic Ablative Radiation Therapy

EP02.02-007. Correlation between Biological Equivalent Dose and Radiological Changes after Lung Stereotactic Ablative Radiation Therapy

Back to course

Pdf Summary

This study aimed to evaluate the radiological changes in patients who undergo lung stereotactic ablative radiation therapy (SABR) and correlate them with the received Biological Equivalent Dose (BED). SABR is commonly used for patients with inoperable early-stage non-small-cell lung cancer. While the probability of grade 2 toxicities is low, there are often radiological subclinical toxicities that present challenges for long-term patient management.<br /><br />The researchers retrospectively analyzed CT scans of 115 patients, evaluating the radiation-related changes 6 months and 2 years after SABR. They assessed the presence of organizing pneumonia pattern, bronchiectasis, extension of consolidative changes, and the percentage of affected lung. Dose-volume histograms of the healthy lung tissue were transformed into BED, and correlations were drawn between BED and radiological toxicities.<br /><br />The results showed a positive and statistically significant correlation between lung BED over 300 Gy and the presence of organizing pneumonia pattern, the degree of lung affectation, and the 2-year prevalence and/or increase of these radiological changes. Patients with BED over 300 Gy to a volume over 30 cc had increased or persistent radiological changes in the 2-year follow-up scan. However, there was no correlation found between radiological changes and the analyzed clinical parameters such as age, smoking habits, and previous pathologies.<br /><br />The study provides important insights into the correlation between BED and radiological changes after SABR for lung cancer treatment. These findings highlight the need for careful monitoring and management of patients to address radiological toxicities that may not be clinically apparent. Future research may further explore the impact of different radiation doses on these radiological changes and patient outcomes.

Asset Subtitle

Carla Cases Copestake

Meta Tag

Speaker Carla Cases Copestake

Topic Early Stage Non-small Cell Lung Cancer - Radiotherapy

Keywords

lung stereotactic ablative radiation therapy

Biological Equivalent Dose

non-small-cell lung cancer

radiological changes

organizing pneumonia pattern

bronchiectasis

consolidative changes

affected lung

dose-volume histograms

radiological toxicities