2022 World Conference on Lung Cancer (ePosters)-EP02.03-016. Dynamics of Recurrence After Curative Resection of Non-small Cell Lung Cancer

EP02.03-016. Dynamics of Recurrence After Curative Resection of Non-small Cell Lung Cancer

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This study examined the trends of recurrence after curative resection of non-small cell lung cancer (NSCLC) by stage. The records of 1,987 patients who underwent surgery for NSCLC between 2007 and 2012 were reviewed. The hazard rate curves for recurrence-free survival (RFS) were analyzed. The study found that the RFS rates at 5 years postoperatively were 87.8%, 54.7%, and 33.4% for stage I, II, and III disease, respectively. The hazard rate for RFS was consistently low in stage I patients for 5 years. In stage II patients, the hazard rate showed a peak at 12.4 months postoperatively, followed by a gradual decrease. In stage III patients, the hazard rate had a higher peak at 13.7 months postoperatively, followed by a gradual decrease. The study also found that patients with EGFR mutation had a higher and later peak of recurrence hazard compared to those without. The hazard rate for the development of second primary lung cancer exceeded that of recurrence of the first primary lung cancer after 72 months postoperatively. It was concluded that short-term surveillance might not be necessary for stage I NSCLC patients, but should be considered for stage II or III disease. Screening for secondary primary lung cancer might be beneficial after more than 6 years postoperatively. Overall, the hazard rate curves for RFS were significantly different according to stage, suggesting the need for individualized surveillance strategies after surgery for NSCLC.

Asset Subtitle

Masaya Yotsukura

Meta Tag

Speaker Masaya Yotsukura

Topic Early Stage Non-small Cell Lung Cancer - Surgery

Keywords

recurrence

curative resection

NSCLC

stage

hazard rate curves

RFS rates

EGFR mutation

second primary lung cancer

surveillance strategies

surgery