2022 World Conference on Lung Cancer (ePosters)-EP03.01-001. Is Airflow Limitation a CausalFactor for Lung Squamous Cell Carcinoma? Evidence from Mendelian Randomization Analysis

EP03.01-001. Is Airflow Limitation a CausalFactor for Lung Squamous Cell Carcinoma? Evidence from Mendelian Randomization Analysis

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A study conducted by researchers at the Guangzhou Institute of Respiratory Health examined the relationship between airflow limitation and lung squamous cell carcinoma (LUSC). It is still unclear whether airflow restriction causes LUSC, so the researchers used genetic instruments and summary data from genome-wide association studies (GWAS) to conduct a Mendelian randomization (MR) analysis.<br /><br />In the two-sample MR analysis, the researchers found that genetic predisposition towards airflow limitation was associated with an increased risk of LUSC. They also conducted a multivariable MR analysis, which took into account the causal effect of airflow limitation and other factors such as cigarette smoking. The analysis still showed a causal effect of airflow limitation on LUSC.<br /><br />The results of the analysis are summarized in Table 1 and Table 2. The two-sample MR analysis showed that airflow limitation and smoking behaviors were both associated with an increased risk of LUSC. The multivariable MR analysis further confirmed the causal effect of airflow limitation on LUSC, even after controlling for smoking, alcohol drinking, and body mass index (BMI).<br /><br />The researchers concluded that MR analysis provided evidence that airflow limitation is likely to be a predictor of LUSC. However, it should be noted that the study has its limitations, such as the reliance on genetic instruments and summary data, as well as the potential for unmeasured confounding factors.<br /><br />Overall, this study suggests that airflow limitation may play a causal role in the development of lung squamous cell carcinoma. Further research is needed to better understand the mechanisms underlying this relationship and to explore potential interventions or preventive measures.

Asset Subtitle

Qing Zhang

Meta Tag

Speaker Qing Zhang

Topic Epidemiology

Keywords

Guangzhou Institute of Respiratory Health

airflow limitation

lung squamous cell carcinoma

LUSC

genetic instruments

genome-wide association studies

Mendelian randomization

smoking behaviors

causal effect

multivariable MR analysis