2022 World Conference on Lung Cancer (ePosters)-EP03.01-002. Co-occurring Mutations, Smoking Status and Prognosis of Early-stage Resected NSCLCs with EGFR Mutations

EP03.01-002. Co-occurring Mutations, Smoking Status and Prognosis of Early-stage Resected NSCLCs with EGFR Mutations

Pdf Summary

A retrospective study was conducted to investigate the association between co-occurring mutations, smoking status, and prognosis in patients with early-stage non-small cell lung cancer (NSCLC) with EGFR mutations. The study included 104 patients diagnosed between 2014 and 2019 at Princess Margaret Cancer Centre in Toronto, Canada.<br /><br />The study utilized next-generation sequencing to analyze tissue molecular testing from commercially available panels. Patients with multiple primary tumors, unknown smoking status, missing sequencing data for certain mutations, or on adjuvant targeted therapy or chemotherapy were excluded from the analysis.<br /><br />The results showed no significant difference in the rates of co-mutations in early-stage EGFR-mutated NSCLC based on smoking status. However, among never-smokers, patients with co-mutations had worse overall survival (OS) compared to those with single EGFR mutations.<br /><br />The study also found that co-mutations in early-stage EGFR-mutated NSCLC may negatively influence survival. However, due to the limited sample size, the results should be interpreted with caution.<br /><br />Overall, this study provides insights into the impact of co-occurring mutations and smoking status on the prognosis of early-stage NSCLC with EGFR mutations. The findings suggest that co-mutations may be associated with worse survival outcomes, particularly in never-smokers. Further research with larger sample sizes is needed to validate these findings and explore the underlying mechanisms.

Asset Subtitle

Alison Moore

Meta Tag

Speaker Alison Moore

Topic Epidemiology

Keywords

retrospective study

co-occurring mutations

smoking status

prognosis

early-stage NSCLC

EGFR mutations

next-generation sequencing

overall survival

never-smokers

limited sample size