2022 World Conference on Lung Cancer (ePosters)-EP03.01-006. Familial Aggregation in Non-small Cell Lung Cancer

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This study examined the familial aggregation of non-small cell lung cancer (NSCLC) among patients in the Indian subcontinent. While lung cancer is commonly associated with tobacco use, familial clustering suggests a possible genetic predisposition. It was found that familial aggregation of NSCLC is common in Indian patients, particularly in females and those without driver mutations. This aggregation was more likely to involve malignancies related to tobacco use, such as head and neck cancer and lung cancer, rather than non-tobacco-related malignancies. This raises the possibility of a common genetic susceptibility gene or shared environmental exposures as contributing factors. <br /><br />The study involved a single-center cross-sectional observational design, enrolling NSCLC patients aged 18 and above who attended a lung cancer clinic between August 2020 and January 2021. Participants underwent in-person interviews and their three-generation pedigrees were constructed. Demographic and clinicopathological information was recorded from patient case files. Significant family history was defined as the presence of at least one affected first-degree relative or two affected second-degree relatives. <br /><br />The primary outcome of the study was the proportion of NSCLC cases with familial aggregation, while the secondary outcome focused on the clinicopathological profile of NSCLC patients with familial aggregation and their clinical associations. The results showed that out of the 270 patients included in the study, 50 (18%) had a significant family history. Comparing the clinical characteristics between those with and without significant family history, no significant differences were observed in age, histopathology, or stage at diagnosis. However, males and patients without driver mutations were more likely to have significant family history. <br /><br />The study suggests that further research is needed to evaluate the genetic susceptibility in NSCLC, as this could have implications for screening and treatment strategies. Understanding familial aggregation and genetic predisposition may help identify individuals at higher risk and personalize their healthcare management.

Asset Subtitle

Sindhura Durga Chitikela

Meta Tag

Speaker Sindhura Durga Chitikela

Topic Epidemiology

Keywords

familial aggregation

non-small cell lung cancer

NSCLC

Indian subcontinent

genetic predisposition

tobacco use

driver mutations

head and neck cancer

single-center cross-sectional observational design

three-generation pedigrees