2022 World Conference on Lung Cancer (ePosters)-EP03.01-007. Comprehensive Genomic Profile of Advanced Lung Cancer in a Region With the Worst Human Development Index in Brazil

EP03.01-007. Comprehensive Genomic Profile of Advanced Lung Cancer in a Region With the Worst Human Development Index in Brazil

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A study was conducted in northeast Brazil, an area with the lowest human development index in the country, to understand the comprehensive genomic profile of non-small cell lung cancer (NSCLC). The researchers retrospectively analyzed the results of next-generation sequencing (NGS) tests performed on NSCLC patients in their service from May to December 2021.<br /><br />The study included data from 53 patients, with 54% of them being male and the median age being 71 years old. 42% of the patients were smokers or former smokers. The expression of programmed cell death ligand 1 (PD-L1) was analyzed, with 50% of the cases showing negative expression and only 11% having high expression. At the time of diagnosis, 54% of the patients had metastatic cancer.<br /><br />The most common target driver mutations found in the tumor samples were in EGFR, ERBB2, ALK, and ROS1, with respective frequencies of 36%, 8%, 8%, and 8%. TP53 was the most common comutated gene, often associated with EGFR mutations.<br /><br />Tumor mutational burden (TMB) analysis was available for 86% of the cases, with 40% having a low TMB and only 5% having a high TMB.<br /><br />Overall, the genomic profile of the NSCLC patients in this region of Brazil was similar to previous studies, with EGFR alteration as one of the main driver mutations, TP53 alterations as the most common comutated gene, and most patients having a low TMB. PD-L1 expression was also consistent with previous research in Brazil.<br /><br />The findings highlight the importance of understanding the molecular tumor profile of NSCLC patients to personalize treatment options. Further studies are needed in this region to better understand the genomic profile of the population and improve diagnosis and treatment planning. NGS testing is performed in this service as a reflex molecular testing for certain types of lung cancer.

Asset Subtitle

Eldsamira Mascarenhas

Meta Tag

Speaker Eldsamira Mascarenhas

Topic Epidemiology

Keywords

northeast Brazil

human development index

non-small cell lung cancer

NSCLC

next-generation sequencing

NGS tests

PD-L1 expression

metastatic cancer

target driver mutations

tumor mutational burden