2022 World Conference on Lung Cancer (ePosters)-EP03.01-013. Improving the Risk Estimation for Second Primary Lung Cancer after Lung Cancer by Taking Histologic Subtype into Account

EP03.01-013. Improving the Risk Estimation for Second Primary Lung Cancer after Lung Cancer by Taking Histologic Subtype into Account

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This study aimed to assess the estimation of the risk for second primary lung cancer (SPLC) after lung cancer (LC) by taking histologic subtype into account. Current standardized incidence ratios (SIR) for SPLC after LC are unexpectedly low in Germany and the UK compared to the United States. The study used data from the German Cancer Registry and the SEER database in the United States. The SIRs were calculated based on age, sex, race, region, and period-specific reference rates. The histologic subtypes of LC were grouped into adenocarcinoma, squamous cell carcinoma (SCC), carcinoid, other NSCLC, small-cell carcinoma (SCLC), and unspecified. The results showed that the risk of same subtype SPLC was very low in Germany and very high in the United States. When using histology-specific reference rates excluding the same subtype SPLC, the SIRs for Germany increased, while the SIRs for the United States decreased. The study concluded that estimations for the risk of SPLC after LC based on registry data are influenced by different registration practices and the analysis method. Using histology-specific reference rates appears to improve the SIR estimations, especially for registries that require SPLC to have a different histology group. However, differing registration practices remain an obstacle when comparing SIRs across countries. Further evaluation is needed to determine the most suitable methods for determining the risk of second primary cancers in the same location.

Asset Subtitle

Marian Eberl

Meta Tag

Speaker Marian Eberl

Topic Epidemiology

Keywords

risk estimation

second primary lung cancer

histologic subtype

standardized incidence ratios

Germany

United States

German Cancer Registry

SEER database

registration practices

histology-specific reference rates