2022 World Conference on Lung Cancer (ePosters)-EP04.01-005. Lung Cancer Diagnosis Following Emergency Admission: Diagnostic and Therapeutic Pathways and Outcomes Within an Italian Cancer Center

EP04.01-005. Lung Cancer Diagnosis Following Emergency Admission: Diagnostic and Therapeutic Pathways and Outcomes Within an Italian Cancer Center

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This study aimed to analyze the diagnostic and therapeutic care pathways and outcomes of patients with a diagnosis of lung cancer following emergency admission. The study included patients admitted to the Emergency Department of IRCCS Ospedale Policlinico San Martino from January 2018 to June 2021 who were diagnosed with lung cancer during hospitalization. Patients with a prior lung cancer diagnosis or previous oncological care were excluded.<br /><br />A total of 124 patients met the criteria for analysis. The majority of patients were male (65.3%) and smokers (76.6%). The median age was 73 years, and the median Charlson Comorbidity Index was 4. Most patients (87.1%) were admitted due to cancer symptoms. Staging was performed in 94.4% of patients, and biopsies were performed in 83.9% of patients.<br /><br />Among the patients, 89.5% received PD-L1 expression assessment and molecular characterization, with 36.8% having PD-L1 expression 50%. The most common histology was non-small cell lung cancer (89.4%). The median overall survival for the overall population was 3.9 months.<br /><br />Factors associated with shorter overall survival included advanced stage, older age, and higher Charlson comorbidity index. In the subgroup of advanced non-small cell lung cancer, factors associated with longer overall survival were target mutations for first-line treatment and starting a first-line therapy.<br /><br />Treatment choices varied based on histo-molecular analyses, with chemotherapy or chemotherapy plus immunotherapy being the most common treatment (59% of treated patients). Patients with oncogene-addicted disease had acceptable overall survival and a high likelihood of starting treatment.<br /><br />In conclusion, lung cancer diagnosis following emergency department admission is associated with extremely poor outcomes. However, patients with oncogene-addicted disease have better overall survival and a higher likelihood of receiving treatment. Further studies are needed to improve early molecular diagnostics and identify predictive factors for oncogene-addiction in patients diagnosed with lung cancer during emergency department admission.

Asset Subtitle

Carlo Genova

Meta Tag

Speaker Carlo Genova

Topic Global Health, Health Services Research, and Health Economics - Cost Issues

Keywords

lung cancer

emergency admission

diagnostic care pathways

therapeutic care pathways

overall survival

non-small cell lung cancer

chemotherapy

immunotherapy

oncogene-addicted disease

early molecular diagnostics