2022 World Conference on Lung Cancer (ePosters)-EP05.01-026. Carboplatin Dose Calculations for Patients with Lung Cancer: Significant Dose Differences Found Depending on Dosing Equation

Pdf Summary

A study conducted by Seçkin Akgül and colleagues compared different formulas used to calculate carboplatin doses for lung cancer patients. Carboplatin is a commonly used chemotherapy drug, but dosing can be challenging due to its relationship with renal function. The Cockcroft Gault (CG) formula has historically been used for carboplatin dosing, but it may lead to overestimation or underestimation of renal function. The researchers compared the CG formula to the Modification of Diet in Renal Disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations.<br /><br />The study analyzed the carboplatin dosing of 96 lung cancer patients. Doses were calculated using the eGFR generated by the different equations. The results showed that the MDRD and CKD-EPI equations resulted in comparable doses, while the CG formula diverged significantly. Up to 17% of patients received a carboplatin dose that was at least 20% higher or lower than what the non-CG formulas would have predicted.<br /><br />The data suggested that the CG formula overestimated kidney function in patients with higher body weight and body surface area, while underestimating it in patients with lower body weight and body surface area. The study also demonstrated the potential benefit of using CKD-EPI, as it predicted lower doses for patients who had their CG-derived carboplatin dose reduced following clinical assessment.<br /><br />Based on these findings, the researchers recommend the implementation of CKD-EPI as the new standard of care for carboplatin dosing internationally. They emphasize the significant differences in dosing depending on the formula used and suggest that CKD-EPI provides the most clinically appropriate carboplatin dosing.<br /><br />The study was supported by generous donations from the Wishlist and Sunshine Coast Hospital and Health Service Lung Cancer Research Trust Fund and the Department of Cancer Care Services, Adem Crosby Cancer Centre. The authors thank the patients, the Adem Crosby Cancer Centre, Sunshine Coast Hospital and Health Service, and the Medical Oncology Group of Australia (MOGA) for their support.<br /><br />Overall, this study highlights the importance of accurately dosing carboplatin in lung cancer patients and suggests that the CKD-EPI equation should be used to avoid underdosing or toxicity.

Asset Subtitle

Seçkin Akgül

Meta Tag

Speaker Seçkin Akgül

Topic Locally Advanced Non-small Cell Lung Cancer - Chemoradiotherapy and Radiotherapy

Keywords

carboplatin

lung cancer

chemotherapy drug

renal function

Cockcroft Gault formula

Modification of Diet in Renal Disease

Chronic Kidney Disease Epidemiology Collaboration

eGFR

body weight

body surface area