2022 World Conference on Lung Cancer (ePosters)-EP05.01-027. Uncertain Resection of pN2 NSCLC Patients-survival Analysis of Postoperative Radiotherapy and Driver Gene Mutations

EP05.01-027. Uncertain Resection of pN2 NSCLC Patients-survival Analysis of Postoperative Radiotherapy and Driver Gene Mutations

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Summary:<br /><br />This study aimed to assess the impact of postoperative radiotherapy (PORT) and driver gene mutation status (DGMS) on the survival of patients with uncertain resection of pN2 non-small cell lung cancer (NSCLC). The study included 140 patients, and it was found that PORT significantly prolonged locoregional recurrence-free survival (LRFS), disease-free survival (DFS), and overall survival (OS), but not distant metastasis-free survival (DMFS). Subgroup analysis showed that in patients with negative DGMS, those who received PORT had longer LRFS and DFS compared to those who did not receive PORT. Cox analysis revealed that the number of positive lymph nodes (PLNs) and administration of PORT were independent prognostic factors for DFS, while pathology, PLNs, and DGMS were potential prognostic factors for OS. The study concluded that PORT may improve locoregional recurrence-free and disease-free survival in patients with pN2 NSCLC with positive highest mediastinal lymph nodes, while DGMS significantly impacted OS. Furthermore, only patients with positive driver gene mutations experienced significant overall survival benefits from postoperative radiotherapy. The study suggests that a prospective study is needed to validate these findings for clinical practice.

Asset Subtitle

Qianyue Deng

Meta Tag

Speaker Qianyue Deng

Topic Locally Advanced Non-small Cell Lung Cancer - Chemoradiotherapy and Radiotherapy

Keywords

postoperative radiotherapy

driver gene mutation status

survival

pN2 non-small cell lung cancer

locoregional recurrence-free survival

disease-free survival

overall survival

distant metastasis-free survival

positive lymph nodes

prognostic factors