2022 World Conference on Lung Cancer (ePosters)-EP05.01-028. Thoracic Radiotherapy of Baseline Severe Pulmonary Dysfunction NSCLC Patients and Predictive Analysis for Acute Radiation Pneumonitis

EP05.01-028. Thoracic Radiotherapy of Baseline Severe Pulmonary Dysfunction NSCLC Patients and Predictive Analysis for Acute Radiation Pneumonitis

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This study aimed to evaluate the effectiveness of thoracic radiotherapy for patients with unresectable non-small cell lung cancer (NSCLS) who have severe pulmonary dysfunction and severe acute radiation pneumonitis (SARP). The study analyzed data from 170 patients who were categorized into two groups: a radiotherapy group and a non-radiotherapy group. The average overall survival (OS) in the radiotherapy group was 21.6 months, significantly higher than the 8.9 months in the non-radiotherapy group. Cox analysis revealed that both chemotherapy and radiotherapy were independent prognostic factors for this cohort.<br /><br />The study also examined the predictive factors for SARP in patients undergoing radiotherapy. It found that the ipsilateral lung V10 (ilV10) was an independent predictor of SARP. The area under the curve (AUC) of ilV10 was 0.785, indicating its validity as a predictor. Patients with higher ilV10 had a higher risk of developing SARP compared to those with lower ilV10.<br /><br />Based on these findings, the study concludes that thoracic radiotherapy can provide clinical benefits for NSCLS patients with severe pulmonary dysfunction. Additionally, the study suggests that ilV10 may be involved in predicting the risk of SARP for these patients.<br /><br />In summary, this study demonstrates the efficacy of thoracic radiotherapy in improving overall survival for NSCLS patients with severe pulmonary dysfunction. It also identifies ilV10 as a potential predictor for SARP in these patients. These findings provide valuable insights for the treatment and management of lung cancer patients with deteriorated pulmonary function.

Asset Subtitle

Qianyue Deng

Meta Tag

Speaker Qianyue Deng

Topic Locally Advanced Non-small Cell Lung Cancer - Chemoradiotherapy and Radiotherapy

Keywords

thoracic radiotherapy

non-small cell lung cancer

severe pulmonary dysfunction

severe acute radiation pneumonitis

overall survival

ipsilateral lung V10

SARP

predictive factors

efficacy

deteriorated pulmonary function