2022 World Conference on Lung Cancer (ePosters)-EP05.01-029. Association between DNA Repair Gene Pathway SNPs and Tumour Response in NSCLC Patients Receiving Radiotherapy: A Meta-Analysis

EP05.01-029. Association between DNA Repair Gene Pathway SNPs and Tumour Response in NSCLC Patients Receiving Radiotherapy: A Meta-Analysis

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This study investigated the effect of Single Nucleotide Polymorphisms (SNPs) in the DNA repair gene pathway on tumour response to radiotherapy in Non-Small Cell Lung Cancer (NSCLC) patients. The researchers performed a systematic review and meta-analysis of nine studies involving 1641 patients. They found that the CC genotype of XRCC1 rs25487 was associated with an increased odds of tumour response compared to other genotypes. However, no significant associations were found for other SNPs. The XRCC1 protein is important for the Base Excision Repair (BER) pathway, which repairs single-base lesions. XRCC1 SNPs may affect DNA repair ability by influencing protein expression. Previous studies have also found associations between XRCC1 rs25487 and clinical outcomes in other cancers, as well as predictors of survival in advanced NSCLC patients. The lack of significant findings for other SNPs in this study may be due to the interaction between multiple SNPs in different genetic pathways and the effects of other factors on tumour response. Overall, this study suggests that XRCC1 rs25487 may play a role in tumour response to radiotherapy in NSCLC patients, highlighting the importance of genetic variations in the DNA repair gene pathway.

Asset Subtitle

Timothy Shun Man Chu

Meta Tag

Speaker Timothy Shun Man Chu

Topic Locally Advanced Non-small Cell Lung Cancer - Chemoradiotherapy and Radiotherapy

Keywords

Single Nucleotide Polymorphisms

SNPs

DNA repair gene pathway

tumour response

radiotherapy

Non-Small Cell Lung Cancer

NSCLC patients

systematic review

meta-analysis

XRCC1 rs25487