2022 World Conference on Lung Cancer (ePosters)-EP05.01-036. Role of Nanoparticle Polymeric Micellar Paclitaxel in Reducing Toxicity and Enhancing Efficacy in Non-small Cell Lung Cancer

EP05.01-036. Role of Nanoparticle Polymeric Micellar Paclitaxel in Reducing Toxicity and Enhancing Efficacy in Non-small Cell Lung Cancer

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The study investigated the use of nanoparticle polymeric micellar paclitaxel (Pm-Pac) in reducing toxicity and enhancing efficacy in non-small cell lung cancer (NSCLC). The researchers evaluated the anti-tumor efficacy of Pm-Pac on the A549 cell line and a xenograft tumor model derived from A549 cells. They also examined the toxicity of Pm-Pac in healthy rats and dogs. Additionally, they retrospectively analyzed the antitumor effect and safety profile of Pm-Pac in advanced NSCLC patients.<br /><br />The assessment of mammalian animals showed that 3 to 4-fold doses of Pm-Pac induced similar short-term toxicity compared to 1-fold doses of standard paclitaxel (Sb-Pac) in healthy rats and dogs. The long-term toxicity of Pm-Pac was the dyszoospermia/atrophy of the testis and epididymis. The evaluation of the objective reaction indicated that Pm-Pac had better therapeutic efficacy than Sb-Pac in both the xenograft tumor model and advanced NSCLC patients, without increased toxicity.<br /><br />The study also provided evidence that nanoparticle Pm-Pac potentially prolonged overall survival (OS) with a favorable safety profile in NSCLC patients without pleural metastasis. The findings suggest that Pm-Pac could be a promising treatment option for advanced NSCLC, reducing toxicity and improving efficacy.<br /><br />In conclusion, this study highlights the potential of nanoparticle polymeric micellar paclitaxel (Pm-Pac) in the treatment of NSCLC. The evaluation of its antitumor efficacy and toxicity in both in vitro and in vivo models, as well as in advanced NSCLC patients, provides valuable insights into the development of nanomedicine for chemotherapeutic treatment in NSCLC.

Asset Subtitle

Baohui Han

Meta Tag

Speaker Baohui Han

Topic Locally Advanced Non-small Cell Lung Cancer - Chemoradiotherapy and Radiotherapy

Keywords

nanoparticle polymeric micellar paclitaxel

Pm-Pac

toxicity reduction

efficacy enhancement

non-small cell lung cancer

NSCLC

A549 cell line

xenograft tumor model

animal toxicity evaluation

advanced NSCLC patients