2022 World Conference on Lung Cancer (ePosters)-EP05.02-017. Prognostic Factors Following Induction Therapy for N2 Lung Cancer

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This study examines the prognostic factors for patients with N2 lung cancer who underwent induction therapy followed by surgery. The study included 43 patients who underwent induction therapy between January 2011 and December 2020, with the prognosis surveyed in February 2022.<br /><br />The prognostic factors examined in this study were inflammatory indexes and tumor markers, including GPS, mGPS, NLR, PLR, PI, PNI, and CEA. The researchers used the Kaplan-Meier method to calculate the survival rate and performed comparisons using the log-rank method.<br /><br />The results showed that a presurgical NLR of 3.6 and a CEA level of 5.0 within two months after surgery were associated with a better prognosis. The average age of the patients was 66.3 years, with 40 males and 3 females. The most common histologic type was adenocarcinoma (n=22), followed by squamous cell carcinoma (n=14).<br /><br />The treatments administered included chemoradiotherapy (n=24), chemotherapy alone (n=8), chemotherapy with VEGF inhibitor (n=6), and EGFR-TKI (n=5). Surgery was performed in 37 patients, with lobectomy being the most common procedure. The average observation period was 1157 days, with 19 patients experiencing recurrence and 13 patients dying.<br /><br />Univariate and multivariate analysis revealed that a presurgical NLR of 3.6 and a CEA level of 5.0 within two months after surgery were significant prognostic factors. The five-year overall survival rate was 71.7% for patients with a presurgical NLR of 3.6 and 0.0% for those with a higher NLR. Similarly, the five-year overall survival rate was 70.5% for patients with a CEA level of 5.0 and 21.9% for those with a higher level.<br /><br />In conclusion, this study suggests that a lower presurgical NLR and a lower CEA level within two months after surgery are associated with a better prognosis for patients with N2 lung cancer who undergo induction therapy followed by surgery. These findings may help guide treatment decisions and improve patient outcomes.

Asset Subtitle

Takashi Inoue

Meta Tag

Speaker Takashi Inoue

Topic Locally Advanced Non-small Cell Lung Cancer - Neoadjuvant and Adjuvant Therapy

Keywords

prognostic factors

N2 lung cancer

induction therapy

surgery

inflammatory indexes

tumor markers

Kaplan-Meier method

log-rank method

presurgical NLR

CEA level