2022 World Conference on Lung Cancer (ePosters)-EP05.02-022. Thoracic Radiotherapy May Increase the Risk of Treatment-induced Pneumonitis after Immune Checkpoint Inhibitors: A Meta-Analysis

EP05.02-022. Thoracic Radiotherapy May Increase the Risk of Treatment-induced Pneumonitis after Immune Checkpoint Inhibitors: A Meta-Analysis

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A meta-analysis of 29 studies involving 3,260 cancer patients has found that thoracic radiotherapy (TRT) combined with immune checkpoint inhibitors (ICIs) may increase the risk of treatment-induced pneumonitis. The study aimed to compare the risk of treatment-related pneumonitis between patients treated with TRT combined with immunotherapy and those treated with ICIs or TRT alone.<br /><br />The analysis showed that the pooled rate of any pneumonitis in patient cohorts treated with combined radiation and immunotherapy was 22%, with a rate of grade 2 pneumonitis at 15% and grade 3 pneumonitis at 4%. When comparing patients treated with ICIs combined with TRT to those treated with ICIs alone or TRT alone, the rate of treatment-related pneumonitis was significantly higher in the combined group (30.5% vs. 15.7% for ICIs combined with TRT vs. ICIs or TRT alone, respectively).<br /><br />Subgroup analysis revealed that lung cancer patients had a significantly higher risk of treatment-related pneumonitis compared to other types of cancer patients after ICIs. Additionally, patients who received concurrent TRT did not have a significantly increased risk of treatment-related pneumonitis compared to those treated with sequential TRT and ICIs.<br /><br />The study suggests that patients treated with combined TRT have a higher risk of grade 2 treatment-related pneumonitis compared to patients treated with ICIs or RT alone. They also found that lung cancer patients have a higher risk of treatment-related pneumonitis after ICIs compared to other cancer types.<br /><br />The authors conclude that future studies with larger sample sizes and different drug combinations are needed to further investigate the risk of treatment-induced pneumonitis.

Asset Subtitle

Feng-Ming Spring Kong

Meta Tag

Speaker Feng-Ming Spring Kong

Topic Locally Advanced Non-small Cell Lung Cancer - Neoadjuvant and Adjuvant Therapy

Keywords

meta-analysis

cancer patients

thoracic radiotherapy

immune checkpoint inhibitors

treatment-induced pneumonitis

immunotherapy

lung cancer patients

treatment-related pneumonitis

concurrent TRT

sequential TRT