2022 World Conference on Lung Cancer (ePosters)-EP05.03-009. Prognostic Impact of Tumor Volume Doubling Time for Resected Squamous Cell Carcinoma of the Lung

EP05.03-009. Prognostic Impact of Tumor Volume Doubling Time for Resected Squamous Cell Carcinoma of the Lung

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A study published in the American Journal of Roentgenology, conducted by Collins VP et al. in 1956, found that tumor volume doubling time (VDT) is a useful prognostic factor in resected non-small cell lung cancer (NSCLC). In a more recent study by Setojima Y et al. published in the European Journal of Cardiovascular Surgery in 2020, the 5-year overall survival (OS) rate was reported to be 68.9% in resected NSCLC patients. The study also found that OS and relapse-free survival (RFS) were significantly different depending on the length of VDT (either less than or equal to 400 days or greater than 400 days) in resected NSCLC. Similarly, another study by Setojima Y et al. in the same journal found that OS and RFS were significantly different depending on the length of VDT (either less than or equal to 215 days or greater than 215 days) in resected NSCLC. Furthermore, in the study conducted by Kenta Nakahashi et al. at Yamagata Prefectural Central Hospital, VDT was identified as a useful prognostic factor in resected squamous cell carcinoma of the lung. The study analyzed 156 patients and found that OS, RFS, and cancer-specific survival (CSS) were significantly different depending on the length of VDT (either less than or equal to 100 days or greater than 100 days) in squamous cell carcinoma patients. The study concluded that further data is needed to confirm these results. In addition, the study found that other prognostic factors for squamous cell carcinoma include lymphovascular invasion, tumor budding, and spread through air spaces (STAS). Overall, these studies highlight the importance of VDT in predicting the prognosis of resected lung cancer and suggest the need for further research to validate these findings.

Asset Subtitle

Kenta Nakahashi

Meta Tag

Speaker Kenta Nakahashi

Topic Locally Advanced Non-small Cell Lung Cancer - Surgery

Keywords

tumor volume doubling time

prognostic factor

resected non-small cell lung cancer

5-year overall survival rate

relapse-free survival

squamous cell carcinoma

lymphovascular invasion

tumor budding

spread through air spaces

prognosis of lung cancer