2022 World Conference on Lung Cancer (ePosters)-EP07.01-002. Surgery in Stage I-III Malignant Pleural Mesothelioma: A Surveillance, Epidemiology, and End Results (SEER)- Medicare Analysis 1995-2015

EP07.01-002. Surgery in Stage I-III Malignant Pleural Mesothelioma: A Surveillance, Epidemiology, and End Results (SEER)- Medicare Analysis 1995-2015

Back to course

Pdf Summary

In this study, the researchers aimed to evaluate the role of radical surgery (RS) in stage I-III malignant pleural mesothelioma (MPM) patients and assess the impact of histology and clinical features on outcomes. They analyzed data from the Surveillance, Epidemiology, and End Results (SEER)-Medicare database from 1995 to 2015.<br /><br />The results showed that multimodality treatment, which includes RS with chemotherapy and/or radiation therapy, was associated with improved survival for patients with epithelioid and NOS histology subtypes. It may also be considered for patients with early-stage biphasic disease. On the other hand, non-RS treatment approach could be considered for patients with sarcomatoid histology.<br /><br />The study emphasized the importance of careful patient selection and multidisciplinary evaluation in making surgical decisions for MPM patients. They found that RS alone was associated with increased mortality, particularly in patients with sarcomatoid histology.<br /><br />Furthermore, the researchers reported that RS-based multimodality therapy reduced mortality in patients with epithelioid and NOS disease, even in older individuals and males. There was also a survival benefit observed in early-stage biphasic disease.<br /><br />Overall, the study highlighted the need for tailored surgery in stage I-III MPM patients and emphasized the importance of considering histology and clinical features in treatment decisions. It provides valuable insights for clinicians in managing this challenging disease.

Asset Subtitle

Qian Wang

Meta Tag

Speaker Qian Wang

Topic Mesothelioma, Thymoma, and Other Thoracic Malignancies - Clinical

Keywords

radical surgery

malignant pleural mesothelioma

histology

clinical features

multimodality treatment

survival

biphasic disease

sarcomatoid histology

patient selection

tailored surgery