2022 World Conference on Lung Cancer (ePosters)-EP07.01-004. Long Survivor Epithelioid Pleural Mesotheliomas Are Characterized by Tertiary Lymphoid Structures: An Update to the MATCH Study

EP07.01-004. Long Survivor Epithelioid Pleural Mesotheliomas Are Characterized by Tertiary Lymphoid Structures: An Update to the MATCH Study

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A study has found that long survivor epithelioid pleural mesothelioma (PM) patients have a higher fraction of B lymphocytes compared to shorter survivors. The study analyzed 69 biopsies from the original MATCH study and selected cases with appropriate slides for immunohistopathological revision. The presence of tertiary lymphoid structures (TLS) was confirmed through immunohistochemistry and transcriptomic analysis. The study focused on epithelioid PM and found two distinct transcriptional groups: Group A enriched in short survivors and Group B enriched in long survivors with a higher fraction of B cells. Immunohistochemistry confirmed the presence of lymphoid aggregates in Group B that matched TLS formation. Further assessment of the entire cohort confirmed that B cell infiltration was higher in long survivor epithelioid PM. Transcriptomic expression of CXCL13 and the MS4A1 gene, markers of TLS and CD20 respectively, were also higher in Group B, providing overlap between omics and immunohistopathological data. The study suggests that the presence of TLS might be prognostic and implies a role of the immune system in modulating the aggressiveness of the disease. However, further research is needed to determine how this information can be used to select the optimal candidate for immunotherapy.

Asset Subtitle

Federica Grosso

Meta Tag

Speaker Federica Grosso

Topic Mesothelioma, Thymoma, and Other Thoracic Malignancies - Clinical

Keywords

long survivor epithelioid pleural mesothelioma

B lymphocytes

biopsies

MATCH study

immunohistopathological revision

tertiary lymphoid structures

transcriptomic analysis

transcriptional groups

CXCL13

MS4A1 gene