2022 World Conference on Lung Cancer (ePosters)-EP07.01-011. Integrating PD-L1 Expression to the CALGB Prognostic Scoring System in Malignant Pleural Mesothelioma

EP07.01-011. Integrating PD-L1 Expression to the CALGB Prognostic Scoring System in Malignant Pleural Mesothelioma

Pdf Summary

A study was conducted to assess the prognostic value of programmed death ligand-1 (PD-L1) expression in patients with malignant pleural mesothelioma (MPM) by integrating it into the Cancer and Leukemia Group B (CALGB) prognostic scoring system. The study included 68 patients with locally advanced and metastatic MPM. PD-L1 expression was determined using tumor tissue specimens, and cut-off points of PD-L1 positivity and high PD-L1 expression were defined. The study found that patients with high PD-L1 expression had worse survival outcomes compared to those with low PD-L1 expression. The analysis also showed that a low PD-L1 expression was associated with better progression-free survival and overall survival. CALGB scores were also assessed, and it was observed that patients with a CALGB score of 5 to 6 had the highest number of cases with high PD-L1 expression. Multivariate analysis confirmed that PD-L1 expression was an independent factor for both progression-free survival and overall survival in patients with MPM and a CALGB score of 5 to 6. The study concluded that PD-L1 expression has prognostic implications in patients with advanced MPM, and it is a significant prognostic factor regardless of the CALGB scoring system. This suggests that integrating PD-L1 expression into the CALGB prognostic scoring system could provide additional valuable information for predicting prognosis in MPM patients.

Asset Subtitle

Luis Antonio Cabrera

Meta Tag

Speaker Luis Antonio Cabrera

Topic Mesothelioma, Thymoma, and Other Thoracic Malignancies - Clinical

Keywords

PD-L1 expression

prognostic value

malignant pleural mesothelioma

Cancer and Leukemia Group B

CALGB prognostic scoring system

locally advanced

metastatic MPM

survival outcomes

progression-free survival

overall survival