2022 World Conference on Lung Cancer (ePosters)-EP07.01-014. Mesothelioma-Associated Fibroblasts Enhance Mesothelioma Aggressiveness and Modulate Drug Response

EP07.01-014. Mesothelioma-Associated Fibroblasts Enhance Mesothelioma Aggressiveness and Modulate Drug Response

Pdf Summary

Mesothelioma-associated fibroblasts (Meso-CAF) have been found to play a significant role in enhancing the aggressiveness of mesothelioma and modulating its response to treatment, according to a study conducted by researchers from the Medical University of Vienna. The study aimed to investigate the impact of Meso-CAF on mesothelioma progression and treatment outcomes.<br /><br />The researchers isolated Meso-CAF from surgical specimens of mesothelioma patients and characterized them at the DNA, RNA, and protein level. They found that Meso-CAF exhibited distinct profiles from normal lung fibroblasts, with significant differences in the fraction of actively secreted proteins.<br /><br />In 2D and 3D co-culture models, the presence of Meso-CAF significantly enhanced the proliferation and migration of mesothelioma cells. Meso-CAF also influenced the response of the tumor cells to inhibitors of tumor-associated pathways. Interestingly, the presence of Meso-CAF resulted in an increased sensitivity of tumor cells to cisplatin, a commonly used chemotherapy drug for mesothelioma.<br /><br />The findings of this study provide valuable insights into the role of Meso-CAF in mesothelioma progression and treatment response. The researchers have established Meso-CAF as an experimental platform for further research on mesothelioma. This study highlights the potential of targeting the tumor microenvironment, specifically Meso-CAF, as a therapeutic strategy for mesothelioma.<br /><br />The research was funded by the Berndorf Private Foundation and the City of Vienna Fund for Innovative Interdisciplinary Cancer Research.

Asset Subtitle

Michael Grusch

Meta Tag

Speaker Michael Grusch

Topic Mesothelioma, Thymoma, and Other Thoracic Malignancies - Clinical

Keywords

mesothelioma-associated fibroblasts

Meso-CAF

aggressiveness of mesothelioma

modulating treatment response

Medical University of Vienna

mesothelioma progression

treatment outcomes

tumor microenvironment

cisplatin sensitivity

therapeutic strategy for mesothelioma