2022 World Conference on Lung Cancer (ePosters)-EP07.01-016. Role of Neoadjuvant Chemotherapy in Thymic Tumors

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This study examined the impact of neoadjuvant chemotherapy (NACT) on thymic tumors in patients who underwent tumor resection. A total of 25 patients, consisting of 10 who received NACT and 15 who underwent primary surgery, were included. Data from January 2015 to October 2021 was collected from electronic medical records at the King Hussein Cancer Center.<br /><br />The response to NACT was evaluated using the response evaluation criteria in solid tumors (RECIST) classification, which categorized the effect on tumor burden as complete response, partial response, stable disease, or progressive disease. The study also measured the percentage of necrotic tissue to determine the pathological response.<br /><br />The overall survival rate was found to be 91.2%, with a mean survival of 115 months. Recurrence occurred in 28% of patients, and the NACT group had a higher risk for recurrence compared to those who did not receive induction therapy.<br /><br />The study found that the radiographic and histopathological effect of NACT on thymic tumors was minimal, with the greatest variation in tumor burden seen in Stage IVa. However, regardless of stage, NACT did not significantly improve oncological outcomes compared to upfront surgery.<br /><br />The majority of patients in the study were male, with a mean age of 46.28 at diagnosis. The distribution of patients among stages was similar, and NACT was evenly distributed among Stage III and IV. The effect of NACT on tumor burden based on RECIST criteria was minimal, with most patients showing stable disease.<br /><br />Based on pathological findings, the average necrotic portion of the tumor was 39.5%, with a higher percentage in Stage IVa compared to Stage III.<br /><br />The study suggests further research through multicentric collaborative studies to better understand the impact of induction chemotherapy on thymic tumors.<br /><br />The study also reported the treatment characteristics, surgical views, and histology findings of the thymoma cases included in the analysis. No severe toxicities were reported, except for one patient who developed chemotherapy-induced heart failure and died immediately postoperatively.

Asset Subtitle

Riad Abdeljalil

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Speaker Riad Abdeljalil

Topic Mesothelioma, Thymoma, and Other Thoracic Malignancies - Clinical

Keywords

neoadjuvant chemotherapy

thymic tumors

tumor resection

NACT

response evaluation criteria in solid tumors

RECIST classification

pathological response

overall survival rate

recurrence

oncological outcomes