2022 World Conference on Lung Cancer (ePosters)-EP07.01-026. Primary Pulmonary Ewing'S Sarcoma: Post Hoc Analysis From Two International Multicenter Prospective Randomized Trials

EP07.01-026. Primary Pulmonary Ewing'S Sarcoma: Post Hoc Analysis From Two International Multicenter Prospective Randomized Trials

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Primary pulmonary Ewing sarcoma (ES) is an extremely rare form of cancer that is typically diagnosed in the second decade of life. It usually originates from bony structures in the axial skeleton, pelvis, and femur, but can occur in any part of the body. Pulmonary ES is particularly uncommon, with only a few case reports documented in the literature.<br /><br />A study was conducted to gain a better understanding of primary pulmonary ES. The data for the study were retrieved from two clinical trials, E.W.I.N.G.99 and EWING-2008. A total of 2,969 patients with ES were included, of which 13 (0.4%) had primary pulmonary ES. The median age at diagnosis was 35 years, and seven of the patients (53%) had pleural and/or pleural metastases at the time of diagnosis.<br /><br />The majority of patients (92%) had undergone a biopsy prior to starting multimodal treatment, which included multi-agent chemotherapy and surgical resection. The types of lung resection performed varied, with the most common being wedge resection, lobectomy, and extrapleural pneumonectomy. R0 resection, which means there were no residual tumor cells left behind, was achieved in 50% of patients. Postoperative radiotherapy was administered to 80% of patients.<br /><br />The mean follow-up period for the patients was 33 months, and the overall 5-year survival rate for the entire cohort was 40%. However, the 5-year survival rate for patients who underwent R0 resection was significantly higher at 80%. The study concluded that primary pulmonary ES is rare and often presents as already metastatic disease or a locally extensive tumor. R0 resection offers the best chance for long-term survival.<br /><br />In summary, primary pulmonary Ewing sarcoma is an extremely rare form of cancer that typically presents as already metastatic disease or a locally extensive tumor. Surgical resection with R0 resection, in combination with chemotherapy and radiotherapy, offers the best chance for long-term survival. Further research and studies are needed to better understand this rare cancer and improve treatment outcomes.

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Theresa Stork

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Speaker Theresa Stork

Topic Mesothelioma, Thymoma, and Other Thoracic Malignancies - Clinical

Keywords

primary pulmonary Ewing sarcoma

cancer

diagnosis

age

bony structures

clinical trials

biopsy

multimodal treatment

lung resection

R0 resection