2022 World Conference on Lung Cancer (ePosters)-EP08.01-056. Pemetrexed-Based Chemotherapy Plus ICIs or Bevacizumab as First-Line Strategy for Patients with Lung Adenocarcinoma in Real-World Setting

EP08.01-056. Pemetrexed-Based Chemotherapy Plus ICIs or Bevacizumab as First-Line Strategy for Patients with Lung Adenocarcinoma in Real-World Setting

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This retrospective analysis compared the efficacy of immune checkpoint inhibitors (ICIs) plus chemotherapy versus bevacizumab (Bev) plus chemotherapy in Chinese patients with advanced lung adenocarcinoma (aLUAD). The study included 49 patients who were treated with either pemetrexed-platinum doublet chemotherapy with bevacizumab (PPB) or PD1/PD-L1 based immunotherapy (PPIO) as their first-line treatment. The results showed that the PPIO group had a higher objective response rate (ORR) of 76.5% compared to 56.3% in the PPB group, though this difference was not statistically significant. The median progression-free survival (PFS) was significantly longer in the PPIO group at 17.3 months compared to 7.3 months in the PPB group. The overall survival (OS) was also better in the PPIO group, though not statistically significant. The incidence of adverse events (AEs) was similar between the two groups, with leucopenia being the most common grade 3 AE. PPIO was associated with a higher incidence of grade 3 thrombocytopenia and anemia, but no grade 4 AEs were observed. Overall, the study suggests that pemetrexed-platinum doublet chemotherapy combined with PD1/PD-L1 based ICIs (PPIO) may be a more effective and well-tolerated treatment option compared to Bevacizumab combination (PPB) for Chinese patients with aLUAD in the real-world setting.

Asset Subtitle

Xin Li

Meta Tag

Speaker Xin Li

Topic Metastatic Non-small Cell Lung Cancer - Immunotherapy

Keywords

retrospective analysis

efficacy

immune checkpoint inhibitors

chemotherapy

lung adenocarcinoma

Chinese patients

objective response rate

progression-free survival

overall survival

adverse events