2022 World Conference on Lung Cancer (ePosters)-EP08.02-093. Loss of Tumor Endothelial QKI Expression Results in Pronounced Reductions in Metastasis and Remodeling of the Tumor Microenvironment

EP08.02-093. Loss of Tumor Endothelial QKI Expression Results in Pronounced Reductions in Metastasis and Remodeling of the Tumor Microenvironment

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Loss of QKI expression in tumor endothelial cells (TECs) leads to reduced metastasis and remodeling of the tumor microenvironment (TME), according to a study conducted by researchers at the Lineberger Comprehensive Cancer Center and University of North Carolina. The researchers found that silencing QKI in human umbilical vein endothelial cells (HUVECs) resulted in decreased microvasculature in microdevices, indicating a significant role of QKI in tumor angiogenesis and metastasis development. In animal models of non-small cell lung cancer, loss of QKI in TECs led to reduced metastasis and prolonged survival. Additionally, the microvessel density and vascular branching were reduced in the QKI knock-out group compared to the control group. These findings suggest that targeting tumor endothelial QKI could be a novel therapeutic strategy for controlling tumor angiogenesis and metastasis in non-small cell lung cancer. Further studies will focus on understanding the mechanistic relationship of TEC QKI and cross talk within the TME. The study was supported by grants from the National Institutes of Health, the Lung Cancer Research Foundation, and the North Carolina Biotechnology Translation Research Grant.

Asset Subtitle

lincy edatt

Meta Tag

Speaker lincy edatt

Topic Metastatic Non-small Cell Lung Cancer - Molecular Targeted Treatments

Keywords

QKI expression

tumor endothelial cells

metastasis

tumor microenvironment

QKI silencing

human umbilical vein endothelial cells

microvasculature

tumor angiogenesis

non-small cell lung cancer

microvessel density