2022 World Conference on Lung Cancer (ePosters)-EP08.02-113. Clinico-genomic Characteristics of Patients with Non-small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutations

EP08.02-113. Clinico-genomic Characteristics of Patients with Non-small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutations

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A large-scale cohort study examined the clinico-genomic characteristics of non-small cell lung cancer (NSCLC) patients with EGFR exon 20 insertion mutations (Ex20ins). EGFR Ex20ins occur in 2-5% of NSCLC cases and have recently been targeted by new drugs. The study used data from the LC-SCRUM-Asia project, which aims to identify lung cancer patients with targetable gene alterations. A targeted next generation sequencing approach was used to analyze the cancer-related genes in NSCLC patients. The study found that EGFR Ex20ins accounted for 15% of all EGFR mutations in NSCLC patients. The most common subtype of Ex20ins was A767_V769dupASV, followed by S768_D770dupSVD. The patients with Ex20ins had shorter overall survival and progression-free survival compared to patients with common EGFR mutations (exon19 deletions and exon21 L858R mutation). The study also found that the available tyrosine kinase inhibitors (TKIs) and PD-1/L1 inhibitors had limited clinical benefit for NSCLC patients with Ex20ins. Cytotoxic agent chemotherapies were identified as the standard therapies for these patients. The study concluded that a novel treatment strategy is needed for NSCLC patients with EGFR Ex20ins. The findings of this study highlight the importance of understanding the clinico-genomic characteristics of NSCLC patients with rare EGFR mutations and the need for developing effective treatment approaches for these patients.

Asset Subtitle

Masanobu Okahisa

Meta Tag

Speaker Masanobu Okahisa

Topic Metastatic Non-small Cell Lung Cancer - Molecular Targeted Treatments

Keywords

large-scale cohort study

clinico-genomic characteristics

non-small cell lung cancer

NSCLC

EGFR exon 20 insertion mutations

Ex20ins

LC-SCRUM-Asia project

targetable gene alterations

next generation sequencing

EGFR mutations