2022 World Conference on Lung Cancer (ePosters)-EP08.03-003. Surgery for Primary Tumor is Associated with Prolonged Overall Survival in Patients with Oligometastatic NSCLC

EP08.03-003. Surgery for Primary Tumor is Associated with Prolonged Overall Survival in Patients with Oligometastatic NSCLC

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A recent study conducted at the Thoracic Oncology Clinic of the National Cancer Institute in Mexico City has found that surgery for the primary tumor is associated with prolonged overall survival in patients with oligometastatic non-small cell lung cancer (NSCLC). Oligometastatic NSCLC is considered a distinct entity from a clinical and biological standpoint, and multidisciplinary treatment including local consolidative therapies has been shown to improve survival. The study, which was a retrospective cohort analysis of a prospective database, included patients with synchronous oligometastatic NSCLC who underwent multimodal treatment, including surgery for the primary lung tumor, between January 2010 and December 2020.<br /><br />The results of the study showed that surgery remained an important component of the multimodal treatment for oligometastatic NSCLC. The approach was associated with prolonged survival and low morbidity and mortality in the cohort. The study also found that levels of carcinoembryonic antigen (CEA) could be considered an important predictive factor for overall survival and patient selection, though further research is needed in this area.<br /><br />The study included 27 patients with a mean age of 54.96 years. The majority of patients had adenocarcinoma (85.2%) and 44.4% had a driver mutation. The surgical morbidity rate was 33.3%, with a mortality rate of 3.7%. The median follow-up period was 47.1 months.<br /><br />The findings of this study suggest that surgery for the primary tumor should be considered as part of the treatment strategy in patients with oligometastatic NSCLC. Further research is needed to better understand the role of CEA levels in predicting overall survival and guiding patient selection. Overall, the study highlights the potential benefits of a multidisciplinary approach to treatment in this patient population.

Asset Subtitle

Jose Francisco Corona-Cruz

Meta Tag

Speaker Jose Francisco Corona-Cruz

Topic Metastatic Non-small Cell Lung Cancer Oligometastatic Disease

Keywords

surgery

primary tumor

overall survival

oligometastatic non-small cell lung cancer

NSCLC

multidisciplinary treatment

local consolidative therapies

retrospective cohort analysis

prospective database

morbidity and mortality