2022 World Conference on Lung Cancer (ePosters)-EP08.03-007. Spontaneous Regression in Metastatic Non-small Cell Lung Cancer: A Case Report

EP08.03-007. Spontaneous Regression in Metastatic Non-small Cell Lung Cancer: A Case Report

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This case report discusses a 40-year-old woman with metastatic Non-Small Cell Lung Cancer who experienced spontaneous regression of her cancer. The patient initially presented with pneumonia and dyspnea and underwent a CT scan which revealed bilateral pleural effusion, atelectasis, and a nodule in the left lower lobe. A FDG-PET scan showed increased tracer uptake in the left nodule and left hilar region. Diagnostic pleural drainage and cytological examination confirmed lung adenocarcinoma.<br /><br />Genomic analysis identified an EGFR gene deletion and immunohistochemistry showed a PD-L1 of 50%. However, in December 2021, a WB-CT scan revealed the complete disappearance of the nodule and pleural effusion. The patient then underwent thoracoscopy with multiple pleural biopsies which showed tissue repair.<br /><br />The case was presented at a meeting and the decision was made to follow up with a CT scan after three months. The report also mentions a second opinion on the pathological report, which suggested uncertain findings and a potential differential diagnosis between adenocarcinoma, pneumocytoma, and Atypical Pneumocyte Hyperplasia.<br /><br />This case highlights a rare occurrence of spontaneous regression in metastatic Non-Small Cell Lung Cancer. Further research and follow-up are needed to better understand the mechanisms behind this phenomenon and determine its implications for treatment and prognosis.

Asset Subtitle

Maria La Mantia

Meta Tag

Speaker Maria La Mantia

Topic Metastatic Non-small Cell Lung Cancer Oligometastatic Disease

Keywords

metastatic Non-Small Cell Lung Cancer

spontaneous regression

pneumonia

CT scan

bilateral pleural effusion

nodule

lung adenocarcinoma

EGFR gene deletion

WB-CT scan

tissue repair