2022 World Conference on Lung Cancer (ePosters)-EP08.04-006. Risk Factors of Chemotherapy-Induced Severe Neutropenia in Elderly Lung Cancer: Data From a Regional Hospital in Thailand

EP08.04-006. Risk Factors of Chemotherapy-Induced Severe Neutropenia in Elderly Lung Cancer: Data From a Regional Hospital in Thailand

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Chemotherapy is an effective treatment for non-small cell lung cancer (NSCLC) but can lead to severe neutropenia, which can result in complications and poor outcomes. This study aimed to identify the risk factors for chemotherapy-induced severe neutropenia in elderly patients with advanced-stage NSCLC and its impact on outcomes.<br /><br />The study analyzed data from 134 elderly patients who received chemotherapy for advanced-stage NSCLC. Among them, 14.92% developed severe neutropenia, and 1.5% experienced febrile neutropenia. The infection rate was similar between patients with severe and non-severe neutropenia.<br /><br />The study identified several risk factors for severe neutropenia. Patients with an Eastern Cooperative Oncology Group (ECOG) score of 2-3, a restrictive protein diet, renal disease, metastasis in two organs, low glomerular filtration rate (GFR), or receiving combination platinum chemotherapy were more likely to develop severe neutropenia.<br /><br />However, there were no significant differences in infection rate, progression-free survival (PFS), or overall survival (OS) between patients with severe neutropenia and those without it. This suggests that the development of severe neutropenia does not impact treatment outcomes in elderly patients with advanced-stage NSCLC.<br /><br />In conclusion, this study found that restriction of protein diet and metastasis in two organs were predictive factors for chemotherapy-induced severe neutropenia in elderly patients with advanced-stage NSCLC. These patients should be carefully monitored during chemotherapy but should not expect significant differences in infection rate or treatment outcomes.

Asset Subtitle

Sunee Neesanun

Meta Tag

Speaker Sunee Neesanun

Topic Metastatic Non-small Cell Lung Cancer - Palliative Chemotherapy

Keywords

Chemotherapy

non-small cell lung cancer

NSCLC

severe neutropenia

elderly patients

advanced-stage

risk factors

infection rate

progression-free survival

overall survival