2022 World Conference on Lung Cancer (ePosters)-EP10.01-015. The Role of CT-Scan as a Body Composition Tool in Oncogene-Addicted Advanced Non-Small Cell Lung Cancer (aNSCLC) Patients.

EP10.01-015. The Role of CT-Scan as a Body Composition Tool in Oncogene-Addicted Advanced Non-Small Cell Lung Cancer (aNSCLC) Patients.

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This study aimed to determine the role of CT scans as a body composition tool in patients with oncogene-addicted advanced Non-Small Cell Lung Cancer (aNSCLC). Sarcopenia, a condition characterized by muscle loss, has been linked to shorter survival and increased treatment-related toxicities in these patients. The researchers sought to develop an algorithm that combines radiological data from CT scans with clinical parameters to identify malnourished patients with oncogene-addicted aNSCLC early on.<br /><br />Forty-nine patients participated in the study, and their nutritional status was assessed using BMI, handgrip score, 3-months weight loss percentage, and hemoglobin levels at the start of tyrosine kinase inhibitor (TKI) therapy. Radiological parameters, including total adipose tissue, visceral adipose tissue, and muscle area at the L3 level, were also collected. The correlation between the nutritional parameters and radiological data was analyzed using statistical tests.<br /><br />The results showed a relationship between clinical and radiological parameters. Lower BMI and greater weight loss were associated with lower muscle area and higher total adipose tissue. The type of oncogene mutation also played a role in nutritional features, with differences observed in total adipose tissue and muscle area.<br /><br />The study suggests that CT scans can be a promising tool for optimizing the nutritional pathway in patients with oncogene-addicted aNSCLC. By integrating radiological data with clinical parameters, healthcare professionals can better identify and manage malnourished patients. The findings warrant further investigation on a larger scale in future trials to validate these results.<br /><br />Overall, this study highlights the potential of CT scans as a body composition tool in assessing the nutritional status of patients with oncogene-addicted advanced Non-Small Cell Lung Cancer. Integrating this information with clinical parameters can help optimize patient care and improve outcomes.

Asset Subtitle

Maristella Bungaro

Meta Tag

Speaker Maristella Bungaro

Topic Palliative and Supportive Care

Keywords

CT scans

body composition tool

oncogene-addicted aNSCLC

sarcopenia

muscle loss

malnourished patients

radiological data

clinical parameters

nutritional status

patient care