2022 World Conference on Lung Cancer (ePosters)-EP11.04-002. The Histopathological Reasons for Better Survival of Patients with Lepidic Pattern Dominant Adenocarcinoma

EP11.04-002. The Histopathological Reasons for Better Survival of Patients with Lepidic Pattern Dominant Adenocarcinoma

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In this study, the researchers aimed to investigate the histopathological factors that contribute to better survival in patients with lepidic-pattern dominant adenocarcinoma, a subtype of lung cancer. They retrospectively reviewed the records of 105 patients who had undergone surgery for non-small cell lung cancer between 2011 and 2018.<br /><br />The patients were divided into two groups: lepidic dominant (Group 1) and non-lepidic predominant (Group 2). The researchers analyzed various factors such as age, gender, histopathology, TNM stages, perineural or lymphovascular invasions, and followed up with the patients for an average of 64 months.<br /><br />The findings of the study showed that lepidic predominance was associated with better survival, but it was not an independent factor. The researchers also found a correlation between lepidic predominance and N stage (lymph node involvement) as well as the presence of lymphovascular invasion (LVI) and perineural invasion (PNI).<br /><br />The better survival of patients with lepidic pattern-dominant adenocarcinomas can be attributed to their less invasive tumor features. However, further studies with larger databases should be conducted to support these conclusions.<br /><br />Overall, this study emphasizes the importance of considering histopathological factors, along with TNM staging and patient-related factors, in predicting survival outcomes for lung cancer patients. The findings highlight the potential significance of lepidic predominance as a favorable prognostic factor in adenocarcinoma patients.

Asset Subtitle

Ismail Sarbay

Meta Tag

Speaker Ismail Sarbay

Topic Pathology - Tumour Diagnostics

Keywords

histopathological factors

survival

lepidic-pattern dominant adenocarcinoma

lung cancer

non-small cell lung cancer

retrospective study

TNM stages

perineural invasion

lymphovascular invasion

prognostic factor