2022 World Conference on Lung Cancer (ePosters)-EP13.01-007. Differentiation between heterogeneous GGNs and part solid nodules using histogram on thin-section CT

EP13.01-007. Differentiation between heterogeneous GGNs and part solid nodules using histogram on thin-section CT

Pdf Summary

This study aimed to differentiate between heterogeneous ground-glass nodules (GGNs) and part-solid nodules using grayscale histograms on thin-section CT scans. The study retrospectively reviewed 320 patients with lung adenocarcinoma in stage A. The CT scans were obtained using different scanners, and the images were viewed with lung and mediastinal window settings. Two radiologists independently evaluated the pulmonary nodules and classified them into four groups: pure GGN, heterogeneous GGN, part-solid nodule, and solid nodule. Histogram features were compared between heterogeneous GGNs and part-solid nodules.<br /><br />The study found that certain histogram parameters were useful in differentiating between the two groups. Parameters such as average CT value, standard deviation, area, skewness, entropy, and relative size of the solid component were found to be valuable in distinguishing between heterogeneous GGNs and part-solid nodules. Some histogram parameters were also helpful in differentiating between invasive adenocarcinomas (IVA) and minimally invasive adenocarcinomas (MIA) and adenocarcinomas in situ (AIS). Heterogeneous GGNs were found to be associated with MIA/AIS lesions, while part-solid nodules were associated with IVA.<br /><br />However, there were some limitations to the study. It was conducted retrospectively, the sub-classification of all lung adenocarcinoma cases was not investigated pathologically, and the histogram analyses were based on one axial slice rather than the entire lesion.<br /><br />In conclusion, quantitative evaluations based on grayscale histograms can help differentiate between heterogeneous GGNs and part-solid nodules. This information may be useful in estimating the pathology of invasive adenocarcinomas and minimally invasive adenocarcinomas/adenocarcinomas in situ lesions.

Asset Subtitle

Hirofumi Koike

Meta Tag

Speaker Hirofumi Koike

Topic Pulmonology, Radiology, and Staging

Keywords

ground-glass nodules

part-solid nodules

thin-section CT scans

lung adenocarcinoma

retrospective study

histogram parameters

differentiation

invasive adenocarcinomas

minimally invasive adenocarcinomas

adenocarcinomas in situ