2022 World Conference on Lung Cancer (ePosters)-EP13.01-009. A Modified T Categorization for Pathological Stage I Lung Adenocarcinoma with Lepidic Component in Chinese Population

EP13.01-009. A Modified T Categorization for Pathological Stage I Lung Adenocarcinoma with Lepidic Component in Chinese Population

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A study was conducted to evaluate the impact of a lepidic component on the pathological T classification (pT8) in lung adenocarcinoma and to assess the performance of a modified pathological T classification (pTm) in predicting survival outcomes. The study found that the current pT8 classification may not be suitable for lung adenocarcinoma with a lepidic component, as the lepidic component was found to be an independent protective factor for survival outcomes. Reclassification of lung adenocarcinoma with a lepidic component into the "T1a" category showed a significant improvement in survival prediction. The study retrospectively analyzed 1923 cases of pathological T1-2aN0M0 invasive lung adenocarcinoma (LUAD) that underwent complete resection. Various statistical measures such as the Harrell's concordance index, area under the 5-year time-dependent receiver operating characteristic curve, reclassification improvement, integrated discrimination improvement, and decision curve analysis were calculated to evaluate the reclassification net benefits of pTm in survival prediction. The study concluded that the current pT8 classification may not be appropriate for LUAD with a lepidic component, and reclassifying such cases into the "T1a" category improves the prediction of survival outcomes.

Asset Subtitle

Shenghui Li

Meta Tag

Speaker Shenghui Li

Topic Pulmonology, Radiology, and Staging

Keywords

lepidic component

pathological T classification

pT8

lung adenocarcinoma

pTm

survival outcomes

reclassification

LUAD

complete resection

prediction