2022 World Conference on Lung Cancer (ePosters)-EP13.01-014. Evaluation of Malignancy and Survival in Patients Operated With a Preliminary Diagnosis of Interstitial Lung Disease

EP13.01-014. Evaluation of Malignancy and Survival in Patients Operated With a Preliminary Diagnosis of Interstitial Lung Disease

Back to course

Pdf Summary

The study aimed to evaluate the presence of malignancy and survival outcomes in patients with interstitial lung disease (ILD) who underwent surgery for diagnostic purposes. A total of 122 cases were included in the study, with 79 males and 43 females, between January 2010 and December 2021. All cases underwent videothoracoscopic wedge resection for parenchyma sampling and removal of accompanying nodules. The cases were divided into two groups: those diagnosed with usual interstitial pneumonia (UIP) and those diagnosed with other or unsubtyped ILD (non-UIP). The mean survival was 97.86.7 and 99.47.4 months for the UIP and non-UIP groups, respectively, with no significant difference in survival between the two groups. Survival was significantly lower in patients over the age of 65 and in those with forced vital capacity (FVC) below 60%. Histopathologically, lung malignancy was detected in 16.4% of patients. The most common malignancy type in UIP patients was adenocarcinoma, while squamous cell carcinoma was more common in non-UIP patients. Malignancy was significantly higher in patients with a smoking history of more than 40 pack-years. Patients with malignancy had significantly shorter survival. Antifibrotic drugs were used by a proportion of patients, but there was no significant difference in survival or malignancy development between those using and not using antifibrotic drugs. The study concludes that patients with ILD should be closely monitored for the development of lung cancer, as malignancy worsens the prognosis. The long-term effects of antifibrotic drugs in these patients require further investigation.

Asset Subtitle

Tiffany Melissa Ergin

Meta Tag

Speaker Tiffany Melissa Ergin

Topic Pulmonology, Radiology, and Staging

Keywords

interstitial lung disease

malignancy

survival outcomes

diagnostic surgery

usual interstitial pneumonia

non-UIP

forced vital capacity

lung malignancy

adenocarcinoma

squamous cell carcinoma