2022 World Conference on Lung Cancer (ePosters)-EP13.01-015. Correlation Between CT Signs and Ki67 Expression in Non-small Cell Lung Cancer

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This study aimed to investigate the correlation between CT signs and Ki67 expression in non-small cell lung cancer (NSCLC) and evaluate the value of CT in diagnosing Ki67 expression. Ki67 is closely related to the characteristics of NSCLC proliferation, infiltration, metastasis, and prognosis. However, it can only be detected using immunohistochemistry, which is invasive. On the other hand, CT is a noninvasive imaging tool commonly used for diagnosing and treating lung cancer.<br /><br />The study included 265 cases of NSCLC diagnosed by chest CT scan and confirmed by surgery and pathology. They were divided into two groups based on the percentage of Ki67 expression: high expression (≥20%) and low expression (<20%). Cox-regression analysis and logistic regression model were used to analyze the data.<br /><br />The results showed statistically significant differences between the two groups in various CT signs, including border, density, bronchial inflation sign, nodular/mass type, obstructive emphysema, pleural effusion, enlarged lymph nodes, CTmean, CTmin, SD, and long and short diameters. Logistic regression analysis identified border, density, bronchial inflation sign, obstructive emphysema, multiple enlarged lymph nodes, CTmin, SD, and short diameters as the reliable predictors of Ki67 expression.<br /><br />Furthermore, the ROC curve analysis revealed that the multiparameter model had better diagnostic efficacy compared to individual CT parameters. The area under the curve was 0.909, with a sensitivity of 88.3% and specificity of 83.1%.<br /><br />In conclusion, CT-related parameters, including border, density, bronchial inflation sign, obstructive emphysema, multiple enlarged lymph nodes, and CTmin, SD, and short diameter, can be used to identify Ki67 expression levels in NSCLC. These CT signs may serve as a reference for assessing the proliferative capacity of NSCLC.

Asset Subtitle

Yuanyong Wang

Meta Tag

Speaker Yuanyong Wang

Topic Pulmonology, Radiology, and Staging

Keywords

CT signs

Ki67 expression

non-small cell lung cancer

NSCLC

diagnosis

proliferation

metastasis

immunohistochemistry

noninvasive imaging

predictors