2022 World Conference on Lung Cancer (ePosters)-EP14.01-009. A Comparative Study of Histological Predictors of Outcome in Patients with Lung Typical and Atypical Carcinoids

EP14.01-009. A Comparative Study of Histological Predictors of Outcome in Patients with Lung Typical and Atypical Carcinoids

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This study compared the prognosis of patients with typical and atypical carcinoids of the lung. Atypical carcinoids were found to have a worse prognosis compared to typical carcinoids. The study looked at various factors such as frequency, mitotic rate, recurrence rate, and risk of metastasis to determine which characteristics should lead to a prolonged follow-up time for patients. <br /><br />The study included 100 patients with a histological diagnosis of lung carcinoid from January 2014 to December 2020. Out of the 100 patients, 15 had typical carcinoids and 85 had atypical carcinoids. The recurrence rate was found to be 28.6% in patients with typical carcinoids, compared to 3.2% in patients with atypical carcinoids. The mean time until recurrence for typical carcinoids was 31 months, while it was 25.3 months for atypical carcinoids. The Ki67 expression, a marker of cell proliferation, was also found to be higher in patients with recurrence.<br /><br />There were 11 deaths reported during the study, with one being related to the disease. The mean follow-up time for the patients was 36.25 months. The study suggests that histological characteristics, particularly the percentage of Ki67 expression, may be more relevant than staging in predicting disease recurrence.<br /><br />Based on the findings, the study concludes that patients with typical carcinoids may be discharged early while patients with atypical carcinoids should be kept under surveillance for a minimum of 3-5 years. This highlights the importance of considering histological predictors in determining the follow-up time for patients with lung carcinoids.

Asset Subtitle

Joana Rei

Meta Tag

Speaker Joana Rei

Topic Small Cell Lung Cancer and Neuro-endocrine Tumours - Informing ES-SCLC

Keywords

prognosis

typical carcinoids

atypical carcinoids

lung

recurrence rate

follow-up time

histological diagnosis

Ki67 expression

disease-related death

cell proliferation