2022 World Conference on Lung Cancer (ePosters)-EP14.01-014. Risk Factors for Brain Metastasis in Patients with Small Cell Lung Cancer: A Systematic Review and Meta-analysis

EP14.01-014. Risk Factors for Brain Metastasis in Patients with Small Cell Lung Cancer: A Systematic Review and Meta-analysis

Back to course

Pdf Summary

A systematic review and meta-analysis was conducted to identify risk factors for brain metastases (BM) in patients with small cell lung cancer (SCLC) in order to support better management and design of randomized controlled trials. The study analyzed data from 61 eligible records, including 18 randomized controlled trials and 39 non-randomized controlled trials. A total of 57 factors were reported, but only 10 factors had enough data for meta-analysis. The study found that younger age, higher T stage, and extensive disease (ED) were risk factors for BM in SCLC patients. These findings suggest that prophylactic cranial irradiation (PCI) should be considered for these high-risk patients. Other factors such as gender, performance status, smoking, and treatment dose did not show significant associations with BM. The study also found that PCI decreased the incidence of BM but did not improve overall survival in SCLC patients with ED. Higher PCI dose did not improve overall survival and its impact on BM was conflicting. The study highlighted the need for regular brain imaging and high-quality data in order to better understand the risk factors for BM in SCLC. The authors concluded that individual patient data meta-analysis and well-designed randomized controlled trials are needed to further identify risk factors and confirm the findings.

Asset Subtitle

Lizza Hendriks

Meta Tag

Speaker Lizza Hendriks

Topic Small Cell Lung Cancer and Neuro-endocrine Tumours - Informing ES-SCLC

Keywords

systematic review

meta-analysis

brain metastases

small cell lung cancer

risk factors

management

randomized controlled trials

prophylactic cranial irradiation

incidence

overall survival